CIDEB antibody (AA 204-219)

Catalog No. ABIN1886856

This anti-CIDEB antibody is a Rabbit Polyclonal antibody detecting CIDEB in ELISA and WB. Suitable for Mouse.

Quick Overview for CIDEB antibody (AA 204-219) (ABIN1886856)

Target: CIDEB (Cell Death-Inducing DFFA-Like Effector B (CIDEB))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIDEB antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-CIDEB Antibody

Binding Specificity: AA 204-219

Cross-Reactivity (Details): It has no cross activity to CIDE-A.

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 204 to 219 of murine CIDE-B.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CIDEB

Target: CIDEB (Cell Death-Inducing DFFA-Like Effector B (CIDEB))

Alternative Name: CIDE-B

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.These death signals finally cause the degradation of chromosomal DNA by activated DNase.DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD.DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified.CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD.Expression of CIDE-B induces apoptosis, which is inhibited by DFF45.CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation.CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow.

Molecular Weight: 25 kDa