CIDEB antibody (C-Term)

Catalog No. ABIN499631

The Rabbit Polyclonal anti-CIDEB antibody is suitable to detect CIDEB in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and EIA.

Quick Overview for CIDEB antibody (C-Term) (ABIN499631)

Target: CIDEB (Cell Death-Inducing DFFA-Like Effector B (CIDEB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIDEB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CIDEB Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to CIDE-B.

Purification: Affinity chromatography purified via peptide column

Immunogen: CIDE-B antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human CIDE-B.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CIDE-B antibody can be used for detection of CIDE-B at 0.5 - 1 μg/mLImmunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CIDEB

Target: CIDEB (Cell Death-Inducing DFFA-Like Effector B (CIDEB))

Alternative Name: CIDE-B

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (1,2). Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow. CIDE-B antibody has no cross activity to CIDE-A.Synonyms: CIDE B, CIDEB, Cell Death Activator CIDE-B, Cell Death-Inducing DFFA-Like Effector B

Gene ID: 27141

UniProt: Q9UHD4