ACIN1 antibody (C-Term, cleaved)

Catalog No. ABIN1887792

The Rabbit Polyclonal anti-ACIN1 antibody (ABIN1887792) specifically detects ACIN1 in WB, ELISA and ICC. The antibody is reactive with Human samples.

Quick Overview for ACIN1 antibody (C-Term, cleaved) (ABIN1887792)

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACIN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-ACIN1 Antibody

Binding Specificity: C-Term, cleaved

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids near the C-terminus of the cleaved active peptide p17, which are identical to those of mouse Acinus.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for ACIN1

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Alternative Name: Acinus

Background: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis.CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE.A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus).Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei.Acinus also induces apoptotic chromatin condensation in cells.Acinus is ubiquitously expressed.Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.

Molecular Weight: 220 kDa