CAMK2A antibody (AA 7-20)

Catalog No. ABIN190687

This Rabbit Polyclonal antibody specifically detects CAMK2A in WB. It exhibits reactivity toward Rat.

Quick Overview for CAMK2A antibody (AA 7-20) (ABIN190687)

Target: CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMK2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CAMK2A Antibody

Binding Specificity: AA 7-20

Purpose: Anti-CaMKII Rabbit Polyclonal Antibody

Cross-Reactivity: Chicken, Cow, Guinea Pig, Hamster, Human, Mouse, Rabbit, Rat

Purification: Affinity - Purified

Immunogen: Synthetic peptide corresponding to aa 7-20 (N-terminus) of rat CaMKII delta isoform conjugated to KLH.

Application Details

Application Notes: Immunoblotting: Use at 1-5 μg/mL. A band of ~50-60 kDa is detected.
Immunohistochemistry: use at 1-10 μg/mL.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: This antibody is stable for at least one (1) year at -20°C.

Target Details for CAMK2A

Target: CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))

Alternative Name: CAMK2A

Background: Calcium/calmodulin-dependent protein kinase type II subunit α,Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CaMKII has 28 different isoforms that derive from the alpha, beta, gamma, and delta genes. Misregulation of CaMKII is linked to Alzheimer's disease, Angelman syndrome, and heart arrhythmia.,CaM kinase II subunit α, CaMK-II subunit α, EC 2.7.11.17

Gene ID: 815

NCBI Accession: NP_741960

Pathways: WNT Signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction