BBS5 antibody (AA 108-141)

Catalog No. ABIN1944771

Product Details anti-BBS5 Antibody

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Binding Specificity: AA 108-141

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS5 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Pr, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.

Clone: RB47475

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BBS5 antibody (ABIN1944771)

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Li, Gerdes, Haycraft, Fan, Teslovich, May-Simera, Li, Blacque, Li, Leitch, Lewis, Green, Parfrey, Leroux, Davidson, Beales, Guay-Woodford, Yoder, Stormo, Katsanis, Dutcher: "Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene." in: Cell, Vol. 117, Issue 4, pp. 541-52, (2004) (PubMed).

Target Details for BBS5

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Alternative Name: BBS5 (BBS5 Products)

Synonyms: zgc:56578 antibody, 1700049I01Rik antibody, 2700023J09Rik antibody, Bardet-Biedl syndrome 5 antibody, Bardet-Biedl syndrome 5 (human) antibody, bbs5 antibody, BBS5 antibody, Bbs5 antibody

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Molecular Weight: 38755

Gene ID: 129880

UniProt: Q8N3I7

Pathways: Hedgehog Signaling