CD51 antibody (Cleaved-Lys889)

Catalog No. ABIN1944813

Cited in 2+ publications. The Rabbit Polyclonal anti-CD51 antibody (ABIN1944813) specifically detects CD51 in WB. The antibody is reactive with Human samples.

Quick Overview for CD51 antibody (Cleaved-Lys889) (ABIN1944813)

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD51 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD51 Antibody

Binding Specificity: Cleaved-Lys889

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-CD51 antibody (ABIN1944813)

Sims, Field, Barnes, Shaikh, Ellington, Murphy, Spurr, Campbell: "Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51." in: Cytogenetics and cell genetics, Vol. 89, Issue 3-4, pp. 268-71, (2000) (PubMed).

Suzuki, Argraves, Arai, Languino, Pierschbacher, Ruoslahti: "Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs." in: The Journal of biological chemistry, Vol. 262, Issue 29, pp. 14080-5, (1987) (PubMed).

Target Details for CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Alternative Name: ITGAV

Background: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Molecular Weight: 116038 Da

Gene ID: 3685

UniProt: P06756

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex