The Rabbit Polyclonal anti-Prostacyclin Receptor antibody has been validated for WB and IF. It is suitable to detect Prostacyclin Receptor in samples from Human. There are 4+ publications available.
PTGIR
Reactivity: Human
WB, ELISA, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
IF: 1:100. WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Storage
4 °C,-20 °C
Ogawa, Tanaka, Inoue, Yoshitake, Isse, Nakagawa, Usui, Itoh, Yoshimasa, Narumiya: "Structural organization and chromosomal assignment of the human prostacyclin receptor gene." in: Genomics, Vol. 27, Issue 1, pp. 142-8, (1995) (PubMed).
Boie, Rushmore, Darmon-Goodwin, Grygorczyk, Slipetz, Metters, Abramovitz: "Cloning and expression of a cDNA for the human prostanoid IP receptor." in: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 12173-8, (1994) (PubMed).
Katsuyama, Sugimoto, Namba, Irie, Negishi, Narumiya, Ichikawa: "Cloning and expression of a cDNA for the human prostacyclin receptor." in: FEBS letters, Vol. 344, Issue 1, pp. 74-8, (1994) (PubMed).
Nakagawa, Tanaka, Usui, Harada, Sasaki, Itoh, Yoshimasa, Namba, Narumiya, Nakao: "Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system." in: Circulation, Vol. 90, Issue 4, pp. 1643-7, (1994) (PubMed).
Target
Prostacyclin Receptor (PTGIR)
Alternative Name
Prostacyclin Receptor
Background
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.