FA13A (Cleaved-Gly39) antibody

Catalog No. ABIN1944829

Product Details

Target: FA13A

Binding Specificity: Cleaved-Gly39

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Isotype: IgG1

Application Details

Application Notes: WB: 1:500- 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References

Ichinose, Davie: "Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 16, pp. 5829-33, (1988) (PubMed).

Ichinose, Hendrickson, Fujikawa, Davie: "Amino acid sequence of the a subunit of human factor XIII." in: Biochemistry, Vol. 25, Issue 22, pp. 6900-6, (1987) (PubMed).

Grundmann, Amann, Zettlmeissl, Küpper: "Characterization of cDNA coding for human factor XIIIa." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 21, pp. 8024-8, (1986) (PubMed).

Target Details

Target: FA13A

Background: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Molecular Weight: 83267 Da

Gene ID: 2162

UniProt: P00488