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CD1c antibody (PE)

CD1C Reactivity: Human FACS Host: Mouse Monoclonal L161 PE
Catalog No. ABIN1981893
  • Target See all CD1c (CD1C) Antibodies
    CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
    Reactivity
    • 46
    • 3
    • 3
    • 1
    • 1
    Human
    Host
    • 26
    • 19
    • 1
    Mouse
    Clonality
    • 28
    • 18
    Monoclonal
    Conjugate
    • 24
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    This CD1c antibody is conjugated to PE
    Application
    • 28
    • 27
    • 12
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    human thymocytes
    Clone
    L161
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD1C Primary Antibody
  • Application Notes
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Comment

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze. Avoid prolonged exposure to light.
    Do not use after expiration date stamped on vial label.
    Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Scharf, Li, Hawk, Garzón, Zhang, Fox, Kazen, Shah, Haddadian, Gumperz, Saghatelian, Faraldo-Gómez, Meredith, Piccirilli, Adams: "The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation." in: Immunity, Vol. 33, Issue 6, pp. 853-62, (2010) (PubMed).

    del C Salamone, Mendiguren, Salamone, Fainboim: "Membrane trafficking of CD1c on activated T cells." in: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 567-77, (2001) (PubMed).

    Briken, Jackman, Watts, Rogers, Porcelli: "Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens." in: The Journal of experimental medicine, Vol. 192, Issue 2, pp. 281-8, (2000) (PubMed).

    Todate, Chida, Suda, Imokawa, Sato, Ide, Tsuchiya, Inui, Nakamura, Asada, Hayakawa, Nakamura: "Increased numbers of dendritic cells in the bronchiolar tissues of diffuse panbronchiolitis." in: American journal of respiratory and critical care medicine, Vol. 162, Issue 1, pp. 148-53, (2000) (PubMed).

  • Target
    CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
    Alternative Name
    CD1c (CD1C Products)
    Synonyms
    BDCA1 antibody, CD1 antibody, CD1A antibody, R7 antibody, CD1c molecule antibody, CD1C antibody
    Background
    CD1c molecule,CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.,R7, BDCA1
    Gene ID
    911
    UniProt
    P29017
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