Endothelin 1 antibody (C-Term)

Catalog No. ABIN198265

This Mouse Monoclonal antibody specifically detects Endothelin 1 in IHC, RIA and IHC (fro). It exhibits reactivity toward Human and Monkey.

Quick Overview for Endothelin 1 antibody (C-Term) (ABIN198265)

Target: Endothelin 1 (EDN1)

Reactivity: Human, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endothelin 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Radioimmunoassay (RIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 1C4

Product Details anti-Endothelin 1 Antibody

Binding Specificity: C-Term

Specificity: Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10 % reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0 mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.

Purification: Protein A purified

Immunogen: C-terminal fragment of human endothelin 1.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.2, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Short term: -20°C
Long term: -20°C.

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: EDN1 / Endothelin 1

Background: Name/Gene ID: EDN1
Family: Hormone

Synonyms: EDN1, Endothelin 1, Endothelin-1, ET1, Preproendothelin-1, PPET1, HDLCQ7

Gene ID: 1906

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size