Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ADAM33 antibody (AA 701-800) (Biotin)

ADAM33 Reactivity: Xenopus laevis WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN2169852
  • Target See all ADAM33 Antibodies
    ADAM33 (ADAM Metallopeptidase Domain 33 (ADAM33))
    Binding Specificity
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 701-800
    Reactivity
    • 22
    • 14
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Xenopus laevis
    Host
    • 32
    • 3
    • 1
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADAM33 antibody is conjugated to Biotin
    Application
    • 27
    • 13
    • 13
    • 9
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Xenopus laevis
    Cross-Reactivity (Details)
    Xenopus laevis
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from Xenopus laevis ADAM13
    Isotype
    IgG
    Top Product
    Discover our top product ADAM33 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    ADAM33 (ADAM Metallopeptidase Domain 33 (ADAM33))
    Alternative Name
    ADAM13 (ADAM33 Products)
    Synonyms
    ADAM13 antibody, ADAM33 antibody, Adaml antibody, adam13 antibody, C20orf153 antibody, DJ964F7.1 antibody, ADAM metallopeptidase domain 33 antibody, disintegrin and metalloproteinase domain-containing protein 19-like antibody, a disintegrin and metallopeptidase domain 33 antibody, ADAM metallopeptidase domain 33 L homeolog antibody, ADAM33 antibody, LOC100230755 antibody, Adam33 antibody, adam33.L antibody
    Background

    Synonyms: NULL

    Background: ADAM13 was first described as a protein expressed in somatic mesoderm and neural crest cells, in developing Xenopus embryos. ADAM13 was also found in liver, heart, and intestines from adult Xenopus. ADAM13 may regulate cellular signaling via Src and Src tyrosine kinase. ADAM13 may also act as a cell attachment molecule, by binding integrins through the cysteine rich domain amoung many other roles. A member of the metalloproteinase family containing disintegrin like domains (ADAMs) the functions of ADAM13 are still poorly understood. ADAM13 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, as well as disintegrin, cysteine rich, EFG like, transmembrane and Cytoplasmic domains. ADAM13 has been shown to be proteolytically active, cleaving fibronectin after binding it to the EGF like domain. ADAM13 is also shed from cells in culture, cleaved aminoterminal from the transmembrane domain, and is released into the culture media. Shed ADAM13 is a 52 kD protein, and can form complexes with a2 macroglobulin, suggesting it is a competent protease. Xenopus ADAM13 has greatest homology with human ADAM 33 (51 % identical), and is 46 % identical with human or mouse ADAM12 or ADAM19. It is still unclear if any of these ADAMs are species orthologs of Xenopus ADAM13, but there are significant differences between the related sequences, suggesting that ADAM13 may be a unique protein. The full length Xenopus ADAM13 sequence codes for a 914 amino acid protein. Predicted mass is 99.749 kD, but glycosylation and cyteine rich regions give Xenopus ADAM13 an apparent MW of 120 kD unprocessed, and 97 kD processed forms, on reduced SDS PAGE gels. ADAM13 contains a putative furin cleavage site, suggesting that a prohormone convertase cleaves the propeptide domain away from the catalytic domain

You are here:
Support