Claudin 23 antibody (AA 25-81) (Cy3)

Catalog No. ABIN2173213

This Rabbit Polyclonal antibody specifically detects Claudin 23 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for Claudin 23 antibody (AA 25-81) (Cy3) (ABIN2173213)

Target: Claudin 23 (CLDN23)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 23 antibody is conjugated to Cy3

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Claudin 23 Antibody (Cy3)

Binding Specificity: AA 25-81

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Claudin 23

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Claudin 23

Target: Claudin 23 (CLDN23)

Alternative Name: Claudin 23

Background:

Synonyms: 2310014B08Rik, Claudin23, CLDN 23, CLDN23, CLDNL.

Background: The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-23, also known as CLDN23 or CLDNL, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family. Expressed in stomach and placenta, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space. Human claudin-23 shares 80 % sequence similarity with its mouse counterpart, suggesting a conserved role between species. Overexpression of claudin-23 is associated with colon tumors, implicating claudin-23 as a possible metastasis factor.

Pathways: Cell-Cell Junction Organization, Hepatitis C