Claudin 23 antibody (AA 25-81) (Biotin)

Catalog No. ABIN2173212

Product Details anti-Claudin 23 Antibody (Biotin)

Target: Claudin 23 (CLDN23)

Binding Specificity: AA 25-81

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 23 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Claudin 23

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Claudin 23

Target: Claudin 23 (CLDN23)

Alternative Name: Claudin 23 (CLDN23 Products)

Synonyms: CLDN23 antibody, CLDNL antibody, hCG1646163 antibody, 2310014B08Rik antibody, claudin 23 antibody, si:ch211-95j8.2 antibody, CLDN23 antibody, si:ch211-95j8.2 antibody, Cldn23 antibody

Background:

Synonyms: 2310014B08Rik, Claudin23, CLDN 23, CLDN23, CLDNL.

Background: The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-23, also known as CLDN23 or CLDNL, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family. Expressed in stomach and placenta, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space. Human claudin-23 shares 80 % sequence similarity with its mouse counterpart, suggesting a conserved role between species. Overexpression of claudin-23 is associated with colon tumors, implicating claudin-23 as a possible metastasis factor.

Pathways: Cell-Cell Junction Organization, Hepatitis C