DEAF1 antibody (AA 211-310) (AbBy Fluor® 555)

Catalog No. ABIN2173561

This Rabbit Polyclonal antibody specifically detects DEAF1 in WB and IF (p). It exhibits reactivity toward Mouse.

Quick Overview for DEAF1 antibody (AA 211-310) (AbBy Fluor® 555) (ABIN2173561)

Target: DEAF1 (Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEAF1 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DEAF1 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 211-310

Cross-Reactivity: Mouse

Predicted Reactivity: Rat,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Deformed Epidermal Autoregulatory Factor 1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DEAF1

Target: DEAF1 (Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1))

Alternative Name: Deformed Epidermal Autoregulatory Factor 1

Background:

Synonyms: DEAF1, Deformed epidermal autoregulatory factor 1 homolog, Nuclear DEA1 related transcriptional regulator, NUDR, SPN, Suppressin, Zinc finger MYND domain containing protein 5, ZMYND5, DEAF1_HUMAN.

Background: Suppressin, also known as DEAF1 is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.

Gene ID: 10522

Pathways: Tube Formation