FRS2 antibody (PE)

Catalog No. ABIN2174228

The Rabbit Polyclonal anti-FRS2 antibody has been validated for WB. It is suitable to detect FRS2 in samples from Human, Mouse and Rat.

Quick Overview for FRS2 antibody (PE) (ABIN2174228)

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS2 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-FRS2 Antibody (PE)

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FRS2

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: Frs2

Background:

Synonyms: FGFR signaling adaptor SNT, FGFR signalling adaptor, FGFR substrate 2, FGFR-signaling adaptor SNT, Fibroblast Growth Factor Receptor Substrate 2, FRS 2, FRS2, FRS2_HUMAN, FRS2A, FRS2alpha, SNT 1, SNT, SNT-1, SNT1, Suc 1 Associated Neurotrophic Factor Target, Suc1 associated neurotrophic factor target 1, Suc1-associated neurotrophic factor target 1.

Background: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.Tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Gene ID: 10818

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2