FRS2 antibody (pTyr436)

Catalog No. ABIN7139006

This Rabbit Polyclonal antibody specifically detects FRS2 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for FRS2 antibody (pTyr436) (ABIN7139006)

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-FRS2 Antibody

Binding Specificity: pTyr436

Purpose: Phospho-FRS2 (Tyr436) Antibody

Cross-Reactivity: Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 436(L-N-Y(p)-I-Q) derived from Human FRS2 .

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2

Background:

Background:

FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Xu H., J. Biol. Chem. 273:17987-17990(1998).
Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
Dhalluin C., Mol. Cell 6:921-929(2000).

Aliases: FGFR signaling adaptor SNT antibody, FGFR signalling adaptor antibody, FGFR substrate 2 antibody, FGFR-signaling adaptor SNT antibody, Fibroblast growth factor receptor substrate 2 antibody, FRS 2 antibody, FRS2 antibody, FRS2_HUMAN antibody, FRS2A antibody, FRS2alpha antibody, SNT 1 antibody, SNT antibody, SNT-1 antibody, SNT1 antibody, Suc 1 Associated Neurotrophic Factor Target antibody, Suc1 associated neurotrophic factor target 1 antibody, Suc1-associated neurotrophic factor target 1 antibody

UniProt: Q8WU20

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2