HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (AA 331-430) antibody (FITC)

Catalog No. ABIN2175625

This Rabbit Polyclonal antibody specifically detects HERV-FRD Provirus Ancestral Env Polyprotein in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (AA 331-430) antibody (FITC) (ABIN2175625)

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 331-430

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Syncytin-2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Alternative Name: Herv-Frd

Background:

Synonyms: envFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD_6p24.1 provirus ancestral Env polyprotein, ERVFRD-1, UNQ6191/PRO20218

Background: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).

Gene ID: 405754

UniProt: P60508