CD14 antibody

Catalog No. ABIN217653

This anti-CD14 antibody is a Mouse Monoclonal antibody detecting CD14 in FACS, WB, ELISA and Func. Suitable for Human, Cynomolgus, Pig, Cow, Sheep, Dog, Rabbit, Goat, Cat, Mink and Llama.

Quick Overview for CD14 antibody (ABIN217653)

Target: CD14

Reactivity: Human, Cynomolgus, Pig, Cow, Sheep, Dog, Rabbit, Goat, Cat, Mink, Llama

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD14 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Functional Studies (Func)

Clone: TÜK4

Product Details anti-CD14 Antibody

Specificity: Recognizes the human CD14 cell surface antigen. CD14 is a 55 KDa glycoprotein that contains multiple leucine-rich repeats. It is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage but a soluble form of CD14 also exists. CD14 is strongly expressed on the surface of monocytes and macrophages but has also been shown to be expressed on the surface of non-myeloid cells. CD14 functions as a pattern recognition receptor, in innate immunity for a variety of ligands, in particular for the LPS (endotoxin) of Gram-negative bacteria. Has been shown to block SDF-induced chemotaxis of U937 cells in a dose-dependent manner.

Purification: Protein G purified

Endotoxin Level: Low Endotoxin

Immunogen:

Type of Immunogen: Native protein

Isotype: IgG2a

Application Details

Application Notes: Approved: ELISA, Flo (1:100 - 1:200), Func, WB

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells or 100 μL whole blood. Method sheets are available on request. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS.

Handling Advice: Store undiluted.

Storage: -20 °C

Storage Comment: -20°C. Store undiluted.

Target Details for CD14

Target: CD14

Alternative Name: CD14

Background: Name/Gene ID: CD14

Synonyms: CD14, CD14 Molecule, CD14 antigen

Gene ID: 929

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades