LRP5 antibody (AA 500-550) (PE)

Catalog No. ABIN2177409

The PE-conjugated Rabbit Polyclonal anti-LRP5 antibody (ABIN2177409) specifically detects LRP5. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LRP5 antibody (AA 500-550) (PE) (ABIN2177409)

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP5 antibody is conjugated to PE

Application: Please inquire

Product Details anti-LRP5 Antibody (PE)

Binding Specificity: AA 500-550

Specificity: This antibody will recognize LRP6 due to high sequence similarity.

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LRP5

Isotype: IgG

Application Details

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for LRP5

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Alternative Name: Lrp5

Background:

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Subcellular location: Extracellular

Synonyms: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2, Low-density lipoprotein receptor-related protein 5, LRP5

Gene ID: 4041

UniProt: O75197

Pathways: WNT Signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation