TSPAN12 antibody (PE)

Catalog No. ABIN2179842

This anti-TSPAN12 antibody is a Rabbit Polyclonal antibody detecting TSPAN12 in FACS. Suitable for Human, Rat and Mouse.

Quick Overview for TSPAN12 antibody (PE) (ABIN2179842)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSPAN12 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-TSPAN12 Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TSPAN12

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C for 12 months.

Target Details for TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Alternative Name: Tspan12

Background: TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. It is a regulator of cell surface receptor signal transduction and plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. It acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. It also acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. It activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP) and activates MMP14/MT1-MMP-dependent cleavage activity.
Synonyms: TSPAN 12, NET 2, NET2, Tetraspan NET 2, Tetraspanin 12, Tetraspanin12, TM4SF12, Transmembrane 4 superfamily member 12, TSN12_HUMAN.

Gene ID: 23554