TSPAN12 antibody (AA 1-100)

Catalog No. ABIN2179830

The Rabbit Polyclonal anti-TSPAN12 antibody (ABIN2179830) specifically detects TSPAN12 in IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for TSPAN12 antibody (AA 1-100) (ABIN2179830)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSPAN12 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TSPAN12 Antibody

Binding Specificity: AA 1-100

Purpose: TSPAN12 Polyclonal Antibody

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TSPAN12

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Alternative Name: TSPAN12

Background:

Synonyms: EVR5, NET2, NET-2, TM4SF12, Tetraspanin-12, Tspan-12, Tetraspan NET-2, Transmembrane 4 superfamily member 12, TSPAN12, UNQ774/PRO1568

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Gene ID: 23554

UniProt: O95859