TLR2 antibody

Catalog No. ABIN2191804

This Mouse Monoclonal antibody specifically detects TLR2 in FACS, Func, IA, IHC (fro) and IP. It exhibits reactivity toward Mouse and has been mentioned in 5+ publications.

Quick Overview for TLR2 antibody (ABIN2191804)

Target: TLR2 (Toll-Like Receptor 2 (TLR2))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func), Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)

Clone: T2-5

Product Details anti-TLR2 Antibody

Cross-Reactivity (Details): Cross reactivity: Human TLR2 : Yes

Sterility: 0.2 μm filtered

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-TLR2 antibody (ABIN2191804)

Brüll, Mensink, van den Hurk, Duijvestijn, Plat: "TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 2951-8, (2010) (PubMed).

Spiller, Elson, Ferstl, Dreher, Mueller, Freudenberg, Daubeuf, Wagner, Kirschning: "TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice." in: The Journal of experimental medicine, Vol. 205, Issue 8, pp. 1747-54, (2008) (PubMed).

Sutmuller, den Brok, Kramer, Bennink, Toonen, Kullberg, Joosten, Akira, Netea, Adema: "Toll-like receptor 2 controls expansion and function of regulatory T cells." in: The Journal of clinical investigation, Vol. 116, Issue 2, pp. 485-94, (2006) (PubMed).

Roura-Mir, Wang, Cheng, Matsunaga, Dascher, Peng, Fenton, Kirschning, Moody: "Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 3, pp. 1758-66, (2005) (PubMed).

Leemans, Stokman, Claessen, Rouschop, Teske, Kirschning, Akira, van der Poll, Weening, Florquin: "Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney." in: The Journal of clinical investigation, Vol. 115, Issue 10, pp. 2894-903, (2005) (PubMed).

Target Details for TLR2

Target: TLR2 (Toll-Like Receptor 2 (TLR2))

Alternative Name: Toll-Like Receptor 2

Background: The monoclonal antibody T2.5 recognizes mouse Toll-like receptor 2 (TLR2). Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. At present, ligands for several of the TLR's, such as TLR2-6,9, have been identified, confirming their role in first line defense against invading microorganism. In mammals, TLRs are identified as type I transmembrane signaling receptors with an extracellular portion containing leucine-rich repeats with pattern recognition capabilities. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing proliferation of proinflammatory cytokines and upregulation of costimulatory molecules and eventually toinitiation of adaptive immunity. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram- positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. It is suggested that TLR2 is able to recognize such a wide variety of PAMPs (pathogen-specific molecular patterns) by forming heterodimers with other TLRs like e.g. TLR6.. TLR2 is essential for recognizing lipopeptides and lipoproteins from several microorganisms and also peptidoglycans derived from gram-positive bacteria. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2. Aliases TLR2, CD282, TIL4 Immunogen Mouse TLR2 peptide

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades