TLR2 antibody (AA 212-242)

Catalog No. ABIN3029164

This Rabbit Polyclonal antibody specifically detects TLR2 in WB, IHC, FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for TLR2 antibody (AA 212-242) (ABIN3029164)

Target: TLR2 (Toll-Like Receptor 2 (TLR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA

Product Details anti-TLR2 Antibody

Binding Specificity: AA 212-242

Purpose: TLR2 Antibody

Cross-Reactivity (Details): Expected species reactivity: Primate

Purification: Purified

Immunogen: A portion of amino acids 212-242 from the human protein was used as the immunogen for this TLR2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TLR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TLR2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TLR2

Target: TLR2 (Toll-Like Receptor 2 (TLR2))

Alternative Name: TLR2

Background: TLR2 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. [UniProt]

UniProt: O60603

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades