C3 antibody

Catalog No. ABIN2192170

This Rabbit Polyclonal antibody specifically detects C3 in WB and IA. It exhibits reactivity toward Rat.

Quick Overview for C3 antibody (ABIN2192170)

Target: C3 (Complement Component 3 (C3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoassay (IA)

Product Details anti-C3 Antibody

Sterility: 0.2 μm filtered

Application Details

Application Notes: For Western blotting and immuno assays, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

Target Details for C3

Target: C3 (Complement Component 3 (C3))

Background: The polyclonal antibody reacts with Rat C3. The complement factor C3 consists of an alpha- and a beta- chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical and mannose binding lectin activation pathways lead to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to formation of the alpha-chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues including renal epithelial cells and hepatocytes.

Pathways: Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling