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PI3 antibody

PI3 Reactivity: Human WB, IHC (p), IA Host: Goat Polyclonal unconjugated
Catalog No. ABIN2192190
  • Target See all PI3 Antibodies
    PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
    Reactivity
    • 47
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 35
    • 11
    • 1
    Goat
    Clonality
    • 36
    • 11
    Polyclonal
    Conjugate
    • 25
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PI3 antibody is un-conjugated
    Application
    • 39
    • 15
    • 13
    • 13
    • 9
    • 9
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)
    Top Product
    Discover our top product PI3 Primary Antibody
  • Application Notes
    For Western blotting and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:100. For Western blotting it is recommended to use non-reducing conditions.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    1 mLdiluted goat serum in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Expiry Date
    12 months
  • Schalkwijk, Wiedow, Hirose: "The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core." in: The Biochemical journal, Vol. 340 ( Pt 3), pp. 569-77, (1999) (PubMed).

    van Bergen, Andriessen, Spruijt, van de Kerkhof, Schalkwijk: "Expression of SKALP/elafin during wound healing in human skin." in: Archives of dermatological research, Vol. 288, Issue 8, pp. 458-62, (1997) (PubMed).

    Pfundt, van Ruissen, van Vlijmen-Willems, Alkemade, Zeeuwen, Jap, Dijkman, Fransen, Croes, van Erp, Schalkwijk: "Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia." in: The Journal of clinical investigation, Vol. 98, Issue 6, pp. 1389-99, (1996) (PubMed).

    Alkemade, van Vlijmen-Willems, van Haelst, van de Kerkhof, Schalkwijk: "Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma." in: The Journal of pathology, Vol. 174, Issue 2, pp. 121-9, (1994) (PubMed).

  • Target
    PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
    Alternative Name
    Elafin/skalp (PI3 Products)
    Synonyms
    ESI antibody, SKALP antibody, WAP3 antibody, WFDC14 antibody, cementoin antibody, trappin-2 antibody, TRAPPIN-2 antibody, elafin antibody, peptidase inhibitor 3 antibody, peptidase inhibitor 3, skin-derived (SKALP) antibody, PI3 antibody
    Background
    Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.
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