Substance P antibody (C-Term)

Catalog No. ABIN230862

The Rat Monoclonal anti-Substance P antibody (Clone NC1-34) (ABIN230862) specifically detects Substance P in IHC, IHC (p), IHC (fro) and IF. The antibody is reactive with Cow samples.

Quick Overview for Substance P antibody (C-Term) (ABIN230862)

Target: Substance P

Reactivity: Cow

Host: Rat

Clonality: Monoclonal

Conjugate: This Substance P antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Clone: NC1-34

Product Details anti-Substance P Antibody

Binding Specificity: C-Term

Specificity: Recognizes the COOH terminal end of substance P, a short polypeptide neurotransmitter that regulates the excitability of dorsal horn nociceptive neurons. It is known to have a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction. 5 % reactivity is observed with eledoisin. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin.

Immunogen: Substance P conjugated to Bovine Serum Albumin.

Isotype: IgG2a

Application Details

Application Notes: Approved: IF, IHC, IHC-Fr (1:100 - 1:200), IHC-P (1:100 - 1:200)

Usage: Immunohistochemistry: This antibody has been used for the localization of substance P in tissue sections by immunofluorescence and PAP staining in nervous systems of experimental animals and man. Please refer to the Cuello references listed below. It has also been successfully applied in archive post-mortem tissues of the human brain, see Mai and Pioro references.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tissue Culture Supernatant, 0.05 % Thimerosal.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for Substance P

Target: Substance P

Alternative Name: TAC1 / Substance P

Background: Name/Gene ID: TAC1
Family: Hormone

Synonyms: TAC1, Hs.2563, Neurokinin 1, Neurokinin 2, Neuromedin L, Neuropeptide K, NK2, NPK, Protachykinin beta, Protachykinin-1, Substance K, Substance P, Tachykinin, precursor 1, Neurokinin A, Neuropeptide gamma, PPT, Neurokinin alpha, NKA, NKNA, TAC2, Tachykinin 2

Gene ID: 6863

UniProt: P20366