CD31 antibody (APC)

Catalog No. ABIN238441

This Mouse Monoclonal antibody specifically detects CD31 in FACS. It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for CD31 antibody (APC) (ABIN238441)

Target: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD31 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: MEM-05

Product Details anti-CD31 Antibody (APC)

Purification: Size-Exclusion Chromatography

Immunogen: Leukocytes of patient suffering from LGL-type leukaemia

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade BSA (Protease free)

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2-8 °C for one month or at -20 °C for longer.

References for anti-CD31 antibody (APC) (ABIN238441)

Soupene, Serikov, Kuypers: "Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells." in: Journal of lipid research, Vol. 49, Issue 5, pp. 1103-12, (2008) (PubMed).

Target Details for CD31

Target: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Alternative Name: CD31 / PECAM1

Background: CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in rebulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.Synonyms: End °CAM, GPIIA', PECAM-1, Platelet endothelial cell adhesion molecule

Gene ID: 9606

UniProt: P16284

Pathways: Regulation of Actin Filament Polymerization