DUSP6 antibody

Catalog No. ABIN2428102

The Rabbit Polyclonal anti-DUSP6 antibody has been validated for ELISA and IHC. It is suitable to detect DUSP6 in samples from Human, Mouse and Rat.

Quick Overview for DUSP6 antibody (ABIN2428102)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-DUSP6 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human DUSP6

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Alternative Name: MKP-3

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades