DUSP6 antibody (AA 58-89)

Catalog No. ABIN392864

The Rabbit Polyclonal anti-DUSP6 antibody is suitable to detect DUSP6 in samples from Human, Mouse and Rat. It has been validated for WB, IF and IHC (p).

Quick Overview for DUSP6 antibody (AA 58-89) (ABIN392864)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB05814

Product Details anti-DUSP6 Antibody

Binding Specificity: AA 58-89

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:2000. WB: 1:500. WB: 1:2000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Alternative Name: DUSP6

Background: DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.

Molecular Weight: 42320

Gene ID: 1848

NCBI Accession: NP_001937, NP_073143

UniProt: Q16828

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades