DUSP6 antibody (AA 1-381)

Catalog No. ABIN560670

Cited in 3+ publications. The Mouse Monoclonal anti-DUSP6 antibody (Clone 3G2) (ABIN560670) specifically detects DUSP6 in WB, ELISA, IF, IHC (p) and RNAi. The antibody is reactive with Human samples.

Quick Overview for DUSP6 antibody (AA 1-381) (ABIN560670)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DUSP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)

Clone: 3G2

Product Details anti-DUSP6 Antibody

Binding Specificity: AA 1-381

Purpose: Mouse monoclonal antibody raised against a full length recombinant DUSP6.

Sequence: MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESLLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ QLYFTTPSNQ NVYQVDSLQS T

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: DUSP6 (AAH03143, 1 a.a. ~ 381 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-DUSP6 antibody (ABIN560670)

Kim, Choi, Han, Lee, Soh, Park, Kim, Park: "TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 12, pp. 1107-20, (2014) (PubMed).

Lee, Huang, Lee, Lee, Ryu, Kim, Kim, Kim, Joung, Kim, Shong, Jo: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, (2012) (PubMed).

Okudela, Yazawa, Woo, Sakaeda, Ishii, Mitsui, Shimoyamada, Sato, Tajiri, Ogawa, Masuda, Takahashi, Sugimura, Kitamura: "Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis." in: The American journal of pathology, Vol. 175, Issue 2, pp. 867-81, (2009) (PubMed).

Target Details for DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Alternative Name: DUSP6

Background: Full Gene Name: dual specificity phosphatase 6
Synonyms: MKP3,PYST1

Gene ID: 1848

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades