PHLDA3 antibody (N-Term)

Catalog No. ABIN2452076

Product Details anti-PHLDA3 Antibody

Target: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Binding Specificity: AA 1-31, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PHLDA3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Specific to human PHLDA3.

Cross-Reactivity (Details): Not tested in other species.

Characteristics: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Purification: Purified

Sterility: Sterile filtered

Immunogen: Synthetic peptide corresponding to N terminal aa 1-31 of human PHLDA3

Clone: 4B6

Isotype: IgG2b kappa

Application Details

Application Notes: Other applications were not tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Preservative: Azide free

Storage: -20 °C/-80 °C

Storage Comment: -20 C (For long term storage: -70 C)

References for anti-PHLDA3 antibody (ABIN2452076)

Kawase, Ohki, Shibata, Tsutsumi, Kamimura, Inazawa, Ohta, Ichikawa, Aburatani, Tashiro, Taya: "PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt." in: Cell, Vol. 136, Issue 3, pp. 535-50, (2009) (PubMed).

Target Details for PHLDA3

Target: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Alternative Name: PHLDA3 (PHLDA3 Products)

Background: PHLDA3 (Pleckstrin homology-like domain family A member 3) is a small PH (Pleckstrin homology) domain-only protein (127 a.a. in human) that is highly conserved in vertebrates. Recently PHLDA3 was found to be a p53-regulated repressor of Akt hence it is speculated as a tumor suppressor. PHLDA3 also inhibits anchorage-independent cell growth. PHLDA3 gene is frequently lost in human lung endocrine tumors.

UniProt: Q9Y5J5