PHLDA3 antibody (AA 43-95) (HRP)

Catalog No. ABIN7163674

Product Details anti-PHLDA3 Antibody (HRP)

Target: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Binding Specificity: AA 43-95

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLDA3 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PHLDA3

Target: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Alternative Name: PHLDA3 (PHLDA3 Products)

Synonyms: TIH1 antibody, Tih1 antibody, si:dz182n13.5 antibody, zgc:92333 antibody, pleckstrin homology like domain family A member 3 antibody, pleckstrin homology like domain, family A, member 3 antibody, pleckstrin homology-like domain, family A, member 3 antibody, PHLDA3 antibody, Phlda3 antibody, phlda3 antibody

Background:

Background: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

Aliases: PHLA3_HUMAN antibody, PHLDA 3 antibody, phlda3 antibody, Pleckstrin homology like domain family A member 2 antibody, Pleckstrin homology like domain family A member 3 antibody, Pleckstrin homology-like domain family A member 3 antibody, TDAG51/Ipl homolog 1 antibody, TDAG51/Ipl homologue 1 antibody, TIH 1 antibody, TIH1 antibody

UniProt: Q9Y5J5