SNRPC antibody (full length)

Catalog No. ABIN2452159

Product Details anti-SNRPC Antibody

Target: SNRPC (Small Nuclear Ribonucleoprotein Polypeptide C (SNRPC))

Binding Specificity: full length

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This SNRPC antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (IF)

Specificity: Specific to human, simian, and mouse U1C.

Cross-Reactivity (Details): Not tested for other species

Purification: Purified

Sterility: Sterile filtered

Immunogen: Recombinant GST-fused mouse U1C (full length)

Clone: 4H12

Isotype: IgG2a kappa

Application Details

Application Notes: 1. Western blotting
2. Immunocytochemistry
3. Immunohistochemistry (frozen section)
4. ELISA
Other applications have not been tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Preservative: Azide free

Storage: -20 °C/-80 °C

Storage Comment: -20 C (For long term storage: -70 C)

References for anti-SNRPC antibody (ABIN2452159)

Pomeranz Krummel, Oubridge, Leung, Li, Nagai: "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution." in: Nature, Vol. 458, Issue 7237, pp. 475-80, (2009) (PubMed).

Muto, Pomeranz Krummel, Oubridge, Hernandez, Robinson, Neuhaus, Nagai: "The structure and biochemical properties of the human spliceosomal protein U1C." in: Journal of molecular biology, Vol. 341, Issue 1, pp. 185-98, (2004) (PubMed).

Target Details for SNRPC

Target: SNRPC (Small Nuclear Ribonucleoprotein Polypeptide C (SNRPC))

Alternative Name: U1 SnRNP C (U1C) (SNRPC Products)

Background: The spliceosomal U1C protein is critical to the initiation and regulation of precursor messenger RNA (pre-mRNA) splicing, as part of the U1 small nuclear ribonucleoprotein particle (snRNP). U1C is needed for efficient complex formation of U1 snRNP with a 5' splice site. The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

UniProt: Q62241, P09234

Pathways: Ribonucleoprotein Complex Subunit Organization