COX18 antibody

Catalog No. ABIN2459950

Product Details anti-COX18 Antibody

Target: COX18 (Cytochrome C Oxidase Assembly Homolog 18 (COX18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COX18.

Application Details

Application Notes: COX18 antibody can be used for detection of COX18 by ELISA at 1:1562500. COX18 antibody can be used for detection of COX18 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store COX18 antibody at -20 °C.

Target Details for COX18

Target: COX18 (Cytochrome C Oxidase Assembly Homolog 18 (COX18))

Alternative Name: COX18 (COX18 Products)

Background: COX18 is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. COX18 is essential for the activity and assembly of cytochrome c oxidase. COX18 plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2, MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).

Molecular Weight: 37 kDa

Gene ID: 285521

NCBI Accession: NP_776188

UniProt: Q8N8Q8