COX18 antibody (Middle Region)

Catalog No. ABIN2786331

The Rabbit Polyclonal anti-COX18 antibody is suitable to detect COX18 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Pig. It has been validated for WB.

Quick Overview for COX18 antibody (Middle Region) (ABIN2786331)

Target: COX18 (Cytochrome C Oxidase Assembly Homolog 18 (COX18))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX18 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COX18 Antibody

Binding Specificity: Middle Region

Purpose: COX18 Antibody - middle region

Sequence: LCSSFVGLSQ NLLLRSPGFR QLCRIPSTKS DSETPYKDIF AAFNTKFISR

Predicted Reactivity: Cow: 79%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 85%, Pig: 86%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against COX18. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COX18

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55716-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for COX18

Target: COX18 (Cytochrome C Oxidase Assembly Homolog 18 (COX18))

Alternative Name: COX18

Background:

Background Information: COX18 is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. COX18 is essential for the activity and assembly of cytochrome c oxidase. COX18 plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2, MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1248 AY957565.1 1-1248 1249-4523 AC095053.3 75071-78345 c

Gene Name: COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)

Alternative Symbols: COX18HS

Protein Name: Mitochondrial inner membrane protein COX18

Molecular Weight: 37kDa

Gene ID: 285521

NCBI Accession: NP_776188

UniProt: Q8N8Q8