MXI1 antibody

Catalog No. ABIN2460213

This anti-MXI1 antibody is a Rabbit Polyclonal antibody detecting MXI1 in WB and ELISA. Suitable for Human, Mouse, Rat and Dog.

Quick Overview for MXI1 antibody (ABIN2460213)

Target: MXI1 (MAX Interactor 1 (MXI1))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MXI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MXI1 Antibody

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MXI1.

Application Details

Application Notes: MXI1 antibody can be used for detection of MXI1 by ELISA at 1:312500. MXI1 antibody can be used for detection of MXI1 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MXI1 antibody at -20 °C.

Target Details for MXI1

Target: MXI1 (MAX Interactor 1 (MXI1))

Alternative Name: MXI1

Background: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors.Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

Molecular Weight: 26 kDa, 21 kDa, 33 kDa

Gene ID: 4601

NCBI Accession: NP_005953

UniProt: P50539

Pathways: Maintenance of Protein Location