KCNN3 antibody

Catalog No. ABIN2461100

The Rabbit Polyclonal anti-KCNN3 antibody has been validated for WB and ELISA. It is suitable to detect KCNN3 in samples from Human, Rat, Mouse and Dog.

Quick Overview for KCNN3 antibody (ABIN2461100)

Target: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Reactivity: Human, Rat, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNN3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KCNN3 Antibody

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNN3.

Application Details

Application Notes: KCNN3 antibody can be used for detection of KCNN3 by ELISA at 1:62500. KCNN3 antibody can be used for detection of KCNN3 by western blot at 2 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store KCNN3 antibody at -20 °C.

Target Details for KCNN3

Target: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Alternative Name: KCNN3

Background: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

Molecular Weight: 81 kDa, 48 kDa

Gene ID: 3782

NCBI Accession: NP_002240

UniProt: Q9UGI6