Adam23 antibody (AA 72-144)

Catalog No. ABIN2467991

The Chicken Polyclonal anti-Adam23 antibody is suitable to detect Adam23 in samples from Human. It has been validated for WB.

Quick Overview for Adam23 antibody (AA 72-144) (ABIN2467991)

Target: Adam23 (ADAM Metallopeptidase Domain 23 (Adam23))

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This Adam23 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Adam23 Antibody

Binding Specificity: AA 72-144

Purification: Immunoaffinity Purified

Application Details

Application Notes: ADAM 23 antibody can be used for the detection of ADAM 23 by Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: ADAM23 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for Adam23

Target: Adam23 (ADAM Metallopeptidase Domain 23 (Adam23))

Alternative Name: ADAM23

Background: FUNCTION: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

SUBUNIT: Ligand for integrin alpha-V/γ,-3.

SIMILARITY: Contains 1 peptidase M12B domain.

SUBCELLULAR LOCATION: Membrane, single-pass type I membrane protein (Potential). Secreted protein. Isoform Gamma.

TISSUE SPECIFICITY: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.

DEVELOPMENTAL STAGE: Highly expressed in the fetal brain.

DOMAIN:A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.

SUMMARY: This protein is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is highly expressed in the brain and may function as an integrin ligand in the brain.

Molecular Weight: 91.9 kDa (calculated)

Gene ID: 8745

NCBI Accession: NP_003803

UniProt: O75077