PDE8B antibody (Internal Region)

Catalog No. ABIN2469456

The Rabbit Polyclonal anti-PDE8B antibody (ABIN2469456) specifically detects PDE8B in IHC. The antibody is reactive with Human, Monkey, Gibbon and Gorilla samples.

Quick Overview for PDE8B antibody (Internal Region) (ABIN2469456)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reactivity: Human, Monkey, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PDE8B Antibody

Binding Specificity: Internal Region

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: PDE8B antibody was raised against a peptide located near the internal domain of PDE8B (Human).

Application Details

Application Notes: PDE8B antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: PDE8B antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B

Background: Phosphodiesterase 8B, is a high affinity, cAMP-specific phosphodiesterase. Enhanced PDE8B activity has been associated with the phenotypic expression of Gsalpha mutations in human pituitary tumors. PDE8B is absent in normal pituitary but present in GH-secreting adenomas. PDE8B activity is inhibited by dipyridamole, but it is insensitive to rolipram, zaprinast, or IBMX.

Gene ID: 8622

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process