MST1R antibody (Internal Region)

Catalog No. ABIN2469459

This anti-MST1R antibody is a Rabbit Polyclonal antibody detecting MST1R in ELISA and IHC. Suitable for Human and Gibbon.

Quick Overview for MST1R antibody (Internal Region) (ABIN2469459)

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reactivity: Human, Gibbon

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MST1R antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MST1R Antibody

Binding Specificity: Internal Region

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FANCE (50 % ).

Purification: Immunoaffinity Chromatography

Immunogen: MST1R antibody was raised against a peptide located near the internal domain of MST1R (Human).

Application Details

Application Notes: MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: MST1R antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for MST1R

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Alternative Name: MST1R

Background: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.

Gene ID: 4486

UniProt: Q04912

Pathways: RTK Signaling