MST1R antibody (Internal Region)

Catalog No. ABIN2469460

This Rabbit Polyclonal antibody specifically detects MST1R in IHC. It exhibits reactivity toward Human, Monkey, Bat and Gorilla.

Quick Overview for MST1R antibody (Internal Region) (ABIN2469460)

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reactivity: Human, Monkey, Bat, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MST1R antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MST1R Antibody

Binding Specificity: Internal Region

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: MST1R antibody was raised against a peptide located near the internal domain of MST1R (Human).

Application Details

Application Notes: MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL, and immunofluorescence.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: MST1R antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for MST1R

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Alternative Name: MST1R

Background: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.

Gene ID: 4486

UniProt: Q04912

Pathways: RTK Signaling