SIRT5 antibody (AA 30-46)

Catalog No. ABIN2470138

This Rabbit Polyclonal antibody specifically detects SIRT5 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SIRT5 antibody (AA 30-46) (ABIN2470138)

Target: SIRT5 (Sirtuin 5 (SIRT5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SIRT5 Antibody

Binding Specificity: AA 30-46

Purification: Protein G Column

Immunogen: SIRT5 antibody was raised against amino acids 30 - 46 of SIRT5 (Human).

Isotype: IgG

Application Details

Application Notes: SIRT5 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 2.5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.05 % BSA, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: SIRT5 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Target Details for SIRT5

Target: SIRT5 (Sirtuin 5 (SIRT5))

Alternative Name: SIRT5

Background: SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Gene ID: 23408

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interactome