SIRT7 antibody (AA 35-51)

Catalog No. ABIN2470139

The Rabbit Polyclonal anti-SIRT7 antibody has been validated for WB and IHC. It is suitable to detect SIRT7 in samples from Human.

Quick Overview for SIRT7 antibody (AA 35-51) (ABIN2470139)

Target: SIRT7 (Sirtuin 7 (SIRT7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SIRT7 Antibody

Binding Specificity: AA 35-51

Purification: Protein G Column

Immunogen: SIRT7 antibody was raised against amino acids 35 - 51 of SIRT7 (Human).

Isotype: IgG

Application Details

Application Notes: SIRT7 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 2.5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Product should be stored long term (months) at -20 °C and short term (weeks) at 4 °C.

Target Details for SIRT7

Target: SIRT7 (Sirtuin 7 (SIRT7))

Alternative Name: SIRT7

Background: SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Gene ID: 51547

UniProt: Q9NRC8