TLX1 antibody (AA 300-330)
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- Target See all TLX1 Antibodies
- TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))
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Binding Specificity
- AA 300-330
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Reactivity
- Mouse, Human, Rat, Cow, Dog, Rabbit, Bat, Monkey, Chicken, Horse, Hamster, Gibbon, Gorilla
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TLX1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Protein G Column
- Immunogen
- TLX1 antibody was raised against amino acids 300 - 330 of TLX1 (Human).
- Isotype
- IgG
- Top Product
- Discover our top product TLX1 Primary Antibody
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- Application Notes
- TLX1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, 0.2 % gelatin, 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies avoid freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- TLX1 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.
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- Target
- TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))
- Alternative Name
- TLX1 (TLX1 Products)
- Synonyms
- Hox-11 antibody, Hox11 antibody, HOX11 antibody, TCL3 antibody, XHox11 antibody, XHox11L2 antibody, hox11 antibody, tlx1-a antibody, TLX-1 antibody, RGD1563655 antibody, SI:dZ46P4.1 antibody, Tlx-1 antibody, ztlx-1 antibody, T cell leukemia, homeobox 1 antibody, T-cell leukemia homeobox 1 antibody, T-cell leukemia homeobox 1 L homeolog antibody, T-cell leukemia, homeobox 1 antibody, Tlx1 antibody, TLX1 antibody, tlx1.L antibody, tlx1 antibody
- Background
- HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35,q24) or t(10:14)(q24,qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
- Gene ID
- 3195
- UniProt
- P31314
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