CBLC antibody (AA 444 - 458)

Catalog No. ABIN2470158

The Rabbit Polyclonal anti-CBLC antibody (ABIN2470158) specifically detects CBLC in WB, ELISA, IHC, IP and IF. The antibody is reactive with Human samples.

Quick Overview for CBLC antibody (AA 444 - 458) (ABIN2470158)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBLC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-CBLC Antibody

Binding Specificity: AA 444 - 458

Purification: Immunoaffinity Chromatography

Immunogen: CBLC antibody was raised against amino acids 444 - 458 of CBLC (Human).

Application Details

Application Notes: CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store CBLC antibody at 4 °C or -20 °C.

Target Details for CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Alternative Name: CBLC

Background: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.

Gene ID: 23624

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway