TGFB1 antibody (AA 286-293)
Quick Overview for TGFB1 antibody (AA 286-293) (ABIN2470323)
Target
See all TGFB1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 286-293
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Purification
- Immunoaffinity Chromatography
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Immunogen
- TGFB1 antibody was raised against Aa 286-293 (of 390) of full-length (including signal peptide) precursor TGFb protein.
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Application Notes
- TGFB1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 10 μg/mL.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- As with all antibodies avoid freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store TGFB1 antibody at 4 °C or -20 °C.
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- TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
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Alternative Name
- TGFB1
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Background
- TGF-beta-1 is a multifunctional cytokine that belongs to a superfamily of structurally related regulatory proteins, which includes three mammalian TGF-beta isoforms (TGF-beta-1, -beta-2, and -beta-3), activin/inhibins and bone morphogenetic proteins. The most abundant isoform, TGF-beta-1, is a 25 kDa homodimer composed of two 12.5 kDa subunits joined by disulfide bonds. TGF-beta-1 is a highly conserved molecule - the amino acid sequence between human and mouse differ only by one residue. Although originally defined by its ability to cause anchorage independent cell growth and changes in cell morphology of rat fibroblasts, subsequent research has revealed that TGF-beta is actually a major growth inhibitor for most cell types. It is produced by a wide variety of cell and tissue types during all stages of cell differentiation. TGF-beta-1 sources include platelets, bone and soft tissues such as placenta and kidneys.
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Gene ID
- 7040
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UniProt
- P01137
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Pathways
- EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
Target
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