Endothelin antibody (C-Term)

Catalog No. ABIN2473437

This anti-Endothelin antibody is a Rat Monoclonal antibody detecting Endothelin in IHC (fro) and IRMA. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for Endothelin antibody (C-Term) (ABIN2473437)

Target: Endothelin

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This Endothelin antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoradiometric Assay (IRMA)

Clone: 3G10

Product Details anti-Endothelin Antibody

Binding Specificity: C-Term

Specificity: Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.

Characteristics: Purified IgG

Purification: Purified

Immunogen: Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

References for anti-Endothelin antibody (ABIN2473437)

Yao, Morioka, Li, Oite: "Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells." in: American journal of physiology. Renal physiology, Vol. 280, Issue 4, pp. F628-35, (2001) (PubMed).

Target Details for Endothelin

Target: Endothelin

Gene ID: 1906, 1907, 1908

UniProt: P05305, P14138, P20800