Neisseria Meningitidis antibody

Details for Product No. ABIN2475826
Antigen
Reactivity
Neisseria meningitidis (N. meningitidis)
16
4
Host
Rabbit
20
Clonality
Polyclonal
Conjugate
Un-conjugated
5
3
3
Application
Immunofluorescence (IF), ELISA
15
10
8
3
3
1
1
1
1
Options
Immunogen Whole cell preparation of N. meningitidis types A, B and C
Isotype IgG
Specificity This antibody reacts with Neisseria meningitidis serogroups A, B and C and is thought to recognize all antigens. Other serogroups have not been tested. N. meningitidis is a gram-negative bacteria that is the causative agent of meningitis. There are 13 known significant serogroups that are classified according to the structure of their polysaccharide capsule. Serogroups, A, B, C, D, X, Y, Z, 29E and W135 are responsible for virtually all cases of the human disease. The carbohydrate component of the capsular membrane induces a T cell independent immune response, so neither long term immunity by memory cell formation nor antibody affinity maturation is observed. Rather than being engulfed and processed by an antigen presenting cell, the carbohydrate capsule interacts directly with B cells. This interaction causes production of serogroup specific antibodies, primarily IgM. IgG is also produced with an IgG1 response predominating in children and an IgG2 response predominating in adults.
Characteristics Purified IgG
Purification Purified
Antigen
Target Type Bacteria
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 4 mg/mL
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