CDKN1A antibody (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1))

Catalog No. ABIN2475991

Product Details anti-CDKN1A Antibody

Target: CDKN1A

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Reactivity: Human

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• Human 291
• Mouse 122
• Rat 83
• Monkey 26
• Chimpanzee 23
• Cow 6
• Sheep 5
• Dog 4
• Pig 3
• Guinea Pig 1
• Hamster 1
• Horse 1
• Non-Human Primate 1
• Primate 1
• Rabbit 1
• Zebrafish (Danio rerio) 1

Host: Mouse

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• Rabbit 222
• Mouse 93
• Chicken 1

Clonality: Monoclonal

Conjugate: This CDKN1A antibody is un-conjugated

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• Un-conjugated 109
• Biotin 24
• HRP 22
• FITC 18
• PE 16
• APC 14
• Alkaline Phosphatase (AP) 14
• Alexa Fluor 750 7
• Alexa Fluor 488 6
• Alexa Fluor 555 6
• Alexa Fluor 594 6
• Alexa Fluor 647 6
• Alexa Fluor 680 6
• Alexa Fluor 350 4
• Cy3 4
• Cy5 4
• Cy5.5 4
• Cy7 4
• CF405M 3
• CF®405S 3
• CF®488A 3
• CF®543 3
• CF®555 3
• CF®568 3
• CF®594 3
• CF®640R 3
• CF®647 3
• CF®660R 3
• CF®680 3
• CF®680R 3
• CF®770 3
• PerCP 3

Application: Immunoprecipitation (IP), Western Blotting (WB)

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• Western Blotting (WB) 157
• ELISA 111
• Immunofluorescence (IF) 97
• Immunohistochemistry (IHC) 81
• Flow Cytometry (FACS) 76
• Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 59
• Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 53
• Dot Blot (DB) 43
• Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 38
• Immunoprecipitation (IP) 21
• Immunocytochemistry (ICC) 15
• Staining Methods (StM) 9
• Enzyme Immunoassay (EIA) 5
• Immunohistochemistry (Frozen Sections) (IHC (fro)) 3
• Proximity Ligation Assay (PLA) 2
• Coating (Coat) 2
• Immunofluorescence (fixed cells) (IF/ICC) 2

Specificity: This antibody recognises the human cyclin-dependent kinase inhibitor p21/WAF1, which is an important cell cycle regulatory protein, also known as CIP1.The p21 protein inhibits cell cycle progression at both the G1 and G2 checkpoints. The expression of p21 is inducible by a wide range of stress stimuli.This antibody detects a band of approximately 21kD in MCF-7 cell lysates following UV radiation.

Characteristics: Purified IgG

Purification: Purified

Immunogen: Human p21 protein

Clone: WA-1

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

References for anti-CDKN1A antibody (ABIN2475991)

Kotala, Uldrijan, Horky, Trbusek, Strnad, Vojtesek: "Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases." in: Cellular and molecular life sciences : CMLS, Vol. 58, Issue 9, pp. 1333-9, 2001 (PubMed).

Kolár, Murray, Scott, Harrison, Vojt?sek, Dusek: "Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer." in: Molecular pathology : MP, Vol. 53, Issue 1, pp. 15-8, 2000 (PubMed).

Target Details for CDKN1A

Target: CDKN1A

Alternative Name: p21/WAF1 (CDKN1A Antibody Abstract)

Synonyms: CCND1, CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, CDKI, Cdkn1, Waf1, mda6, p21Cip1, p21WAF, Cip1, UV96, p21, cip1, p16Xic2, sdi1, waf1, cap20, cdkn1, mda-6, p21cip1, si:ch1073-48m5.2, KRAS2, p21ras, cyclin D1, cyclin dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1A (P21), cyclin-dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1A L homeolog, cyclin-dependent kinase inhibitor 1, KRAS proto-oncogene, GTPase, CCND1, CDKN1A, Cdkn1a, cdkn1a.L, cki1, cdkn1a, KRAS

Gene ID: 1026

UniProt: P38936

Pathways: p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy