PARP1 antibody

Catalog No. ABIN2476185

Cited in 3+ publications. The Mouse Monoclonal anti-PARP1 antibody (Clone A6-4-12) (ABIN2476185) specifically detects PARP1 in WB, ELISA, IF, IP, IHC (p) and IHC (fro). The antibody is reactive with Human, Mouse, Rat, Drosophila melanogaster, Hamster and Xenopus laevis samples.

Quick Overview for PARP1 antibody (ABIN2476185)

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivity: Human, Mouse, Rat, Drosophila melanogaster, Hamster, Xenopus laevis

Host: Mouse

Clonality: Monoclonal

Conjugate: This PARP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: A6-4-12

Product Details anti-PARP1 Antibody

Cross-Reactivity: Fruit Fly (Drosophila melanogaster), Hamster, Mouse (Murine), Rat (Rattus), Xenopus laevis

Characteristics: Purified IgG

Purification: Purified

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

References for anti-PARP1 antibody (ABIN2476185)

Pinton, Manente, Murer, De Marino, Mutti, Moro: "PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1." in: Journal of cellular and molecular medicine, Vol. 17, Issue 2, pp. 233-41, (2013) (PubMed).

Harris, Jakob, Taucher-Scholz, Dianov, Becherel, Lavin: "Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage." in: Human molecular genetics, Vol. 18, Issue 21, pp. 4102-17, (2009) (PubMed).

Freire, dAdda Di Fagagna, Wu, Pedrazzi, Stagljar, Hickson, Jackson: "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha." in: Nucleic acids research, Vol. 29, Issue 15, pp. 3172-80, (2001) (PubMed).

Target Details for PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Alternative Name: POLY(ADP-RIBOSE) POLYMERASE-1

Gene ID: 142

UniProt: P09874

Pathways: Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location